Magnesium L-Threonate
Product Name: Magnesium L-Threonate
Synonyms: Magnesium Threonate, L-threonic acid, magmind, magtein,neuro-mag,Magnesium bis[(2R,3S)-2,3,4-trihydroxybutanoate]
Chemical Name: C8H14MgO10
Specification: 99%
Appearance: White crystalline, odorless
CAS No.: 778571-57-6, 500304-76-7 (hydrate)

Products Description:

 What is Magnesium L-Threonate?
Magnesium L-Threonate is one of the three forms of magnesium chelates in Natural Stacks highly effective nootropic supplement.  Magnesium is an essential mineral,necessary for practically all the tissues in the body, and very important for correct central nervous system functioning.  Magnesium is necessary for correct cognitive functioningin the brain, storing memory, dealing with stress, and obtaining high quality sleep. At the same time, it is thought that many people in industrialised countries are not obtainingenough magnesium through the diet. Unfortunately, many of the more common magnesium supplements fail to increase brain magnesium levels, and hence do not provideany nootropic benefits at all. In a 2010 animal study from MIT, magnesium L-threonate was the only one, of the forms of magnesium studied, which increased theconcentration of the divalent ion in cerebrospinal fluid.


Magnesium is one of the most common cations in the human body, and is involved in over 300 metabolic reactions, including all reactions that require ATP. Magnesium isrequired for cellular energy metabolism, membrane stabilization, nerve conduction, calcium channel activity and ion transporters. Bone contains 50% to 60% of the totalcontent of magnesium in the body. The recommend daily allowance (RDA) of magnesium is 400mg, although a large percentage of the population falls below recommendedintake levels.
L-threonate (2R, 3S)-2,3,4-trihydroxybutyric acid) is an endogenous substqance found in certain plants, as well as human body as a degradation product of vitamin C. It hasbeen identified in human plasma, urine, as well as in the aqueous humor of the eye.
Magnesium L-Threonate is a magnesium salt of L-threonic acid having the molecular formula Mg(C4H7O5)2. Magnesium L-Threonate was found to have a highermagnesium bioavailability compared to magnesium chloride, magnesium citrate, magnesium glycinate and magnesium gluconate.

How does Magnesium L-Threonate work:
Most magnesium supplements are not readily absorbed into the nervous system. Magnesium L-Threonate is able to pass through the blood brain barrier more effectively thanother magnesium forms. Improved brain function is closely associated with the increased synaptic connections in the DG and CA1 sub regions of the Hippocampus that areknown to control memory. The clinical research indicated a greater brain synapse density in subjects taking Magnesium L-Threonate. In preclinical models, L-threonatecontained in Magnesium L-Threonate boosted magnesium levels in spinal fluid by an impressive 15% compared to no increase with conventional magnesium. Even morecompelling, animal models revealed improvements of 18% for short-term memory and 100% for long-term memory using the Magnesium L-Threonate form of magnesium.

Benefits of taking Magnesium L-Threonate supplements:
Magnesium-l-threonate is the form of magnesium that most readily crosses the blood brain barrier. Magnesium-l-threonate can help memory and cognitive functions.Cognitive functions include areas of attention, memory, executive decision, and visual and spatial recognition.

Dosage for magnesium L-Threonate:

Based on the animal study, 1g twice a day with a meal should be sufficient. The human study will provide greater insight into dosing.
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